The basis of our physical world is electrical. The unified Electromagnetic field can appear to us as particles, i.e., matter, at certain densities of wavelengths. A close interrelation therefore exists between matter and electric energy. This knowledge is extensively utilized in technology. Various tools and instruments are electrically powered, utilizing the exceedingly important principle of closed electric circuits. Corresponding closed electric circuits and functions also exist in biology but are more sophisticated and complex. Unfortunately, these aspects are almost unrecognized. The principle of Biologically Closed Electric Circuits (BCEC) and some of their structural and functional effects are described. The Vascular-Interstitial Closed Circuit (VICC) is one specific BCEC system. It functions as a circulatory system in addition to the mechanical circulation. Its efficiency partly depends on its capacity to provide bidirectional transport of ions. The VICC is an in vivo electrophoretic-dielectrophoretic system that is powered by metabolic energy or injury currents. A VICC activation leads to transports of metabolites, new structuring and healing of an injured tissue. Examples are also presented of the process of healing. An abnormal, e.g., prolonged activation of VICC may also induce pathology. Neoplastic formation of cells and tissue can also be healed by the use of artificially applied electrophoresis or an artificially applied electric field as will be described. Our world once developed from electrical energy. This is probably the reason why the BCEC systems make primary differences between nonbiological and biological matter.