Objective: This study was undertaken to investigate the relationship between pregnancy outcome and prepregnancy overweight or obesity in women with a normal glucose tolerance test.
Study design: A historical cohort study of 2459 pregnant women systematically examined for gestational diabetes was performed. Information of oral glucose tolerance test results and clinical outcome were collected from medical records.
Results: The risk of hypertensive complications, cesarean section, induction of labor and macrosomia was significantly increased in both overweight women (body mass index [BMI] 25.0-29.9 kg/m(2)) and obese women (BMI >or= 30.0 kg/m(2)) compared with women who were of normal weight (BMI 18.5-24.9 kg/m(2)). The frequencies of shoulder dystocia, preterm delivery, and infant morbidity other than macrosomia were not significantly associated with maternal BMI.
Conclusion: Prepregnancy overweight and obesity is associated with adverse pregnancy outcome in glucose-tolerant women.