Abstract
The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1beta mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1beta mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.
MeSH terms
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Animals
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Brain Chemistry / genetics*
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Brain Chemistry / immunology
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Cerebral Cortex / cytology
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Cerebral Cortex / immunology
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Cerebral Cortex / metabolism
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Cerebral Ventricles
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Choroid Plexus / cytology
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Choroid Plexus / immunology
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Choroid Plexus / metabolism
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Corpus Striatum / cytology
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Corpus Striatum / immunology
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Corpus Striatum / metabolism
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Corticosterone / blood
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Female
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Genetic Predisposition to Disease
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Hypothalamus / cytology
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Hypothalamus / immunology
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Hypothalamus / metabolism
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Immunity, Innate / genetics
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Inflammation / immunology
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Inflammation / metabolism
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Inflammation / pathology
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Injections, Intraperitoneal
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Interleukin-1 / biosynthesis*
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Interleukin-1 / genetics
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Lipopolysaccharides / administration & dosage*
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RNA, Messenger / biosynthesis*
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Rats
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Rats, Inbred F344
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Rats, Inbred Lew
Substances
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Interleukin-1
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Lipopolysaccharides
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RNA, Messenger
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Corticosterone