New molecular pathways in angiogenesis

Br J Cancer. 2003 Jul 21;89(2):228-31. doi: 10.1038/sj.bjc.6601107.


Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ephrins / pharmacology*
  • Hedgehog Proteins
  • Humans
  • Ligands
  • Membrane Proteins / pharmacology
  • Neoplasms / genetics*
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic / genetics*
  • Receptors, Eph Family / physiology*
  • Receptors, Notch
  • Signal Transduction
  • Trans-Activators / pharmacology


  • Ephrins
  • Hedgehog Proteins
  • Ligands
  • Membrane Proteins
  • Receptors, Notch
  • Trans-Activators
  • Receptors, Eph Family