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. 2003 Jun;69(6):537-41.
doi: 10.1055/s-2003-40634.

Effects of Fucoidan on Chronic Renal Failure in Rats

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Effects of Fucoidan on Chronic Renal Failure in Rats

Quanbin Zhang et al. Planta Med. .

Abstract

The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.

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