A new triterpene from Leandra chaetodon

Qinglin Zhang; Hala N ElSohly; Xing-Cong Li; Larry A Walker

doi:10.1055/s-2003-40646

A new triterpene from Leandra chaetodon

Planta Med. 2003 Jun;69(6):582-4. doi: 10.1055/s-2003-40646.

Authors

Qinglin Zhang¹, Hala N ElSohly, Xing-Cong Li, Larry A Walker

Affiliation

¹ National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Thad Cochran Research Center, School of Pharmacy, The University of Mississippi, University, MS, USA.

PMID: 12865988
DOI: 10.1055/s-2003-40646

Abstract

A new triterpene compound ( 1), along with arjunolic acid, was isolated from an ethanol extract of the whole plant of Leandra chaetodon. Based on spectroscopic analysis, the structure of 1 was determined as 2alpha,6alpha- dihydroxybetulinic acid. Arjunolic acid showed inhibitory activity against Cryptococcus neoformans. (IC50 = 20 micrograms/mL).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antifungal Agents / administration & dosage
Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Cryptococcus neoformans / drug effects*
Humans
Microbial Sensitivity Tests
Myrtaceae*
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Triterpenes / administration & dosage
Triterpenes / pharmacology*
Triterpenes / therapeutic use

Substances

Antifungal Agents
Plant Extracts
Triterpenes