Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats

Pol J Pharmacol. 2002 Nov-Dec;54(6):707-10.


We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / pharmacology*
  • Antidepressive Agents / therapeutic use
  • Cyclopentanes / pharmacology*
  • Cyclopentanes / therapeutic use
  • Dose-Response Relationship, Drug
  • Hippocampus / drug effects
  • Male
  • Rats
  • Rats, Wistar
  • Receptors, Metabotropic Glutamate / agonists*
  • Tricarboxylic Acids / pharmacology*
  • Tricarboxylic Acids / therapeutic use


  • 1-aminocyclopentane-1,2,4-tricarboxylic acid
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Cyclopentanes
  • Receptors, Metabotropic Glutamate
  • Tricarboxylic Acids
  • metabotropic glutamate receptor 3