Yeast RNA helicases of the DEAD-box family involved in translation initiation

Biol Cell. May-Jun 2003;95(3-4):157-67. doi: 10.1016/s0248-4900(03)00032-7.


RNA helicases of the DEAD-box and related families have been found to be required for all processes involving RNA molecules. Biochemical and genetic analyses have shown that at least two RNA helicases are required for translation initiation in yeast. Although it is generally believed that these enzymes are necessary to unwind secondary structures in the 5' untranslated region of mRNAs, their exact role has not been convincingly shown. We discuss here our present knowledge of the function of eIF4A and Ded1p, two DEAD-box proteins required for translation in eukaryotic cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • DEAD-box RNA Helicases
  • Eukaryotic Initiation Factor-4A / genetics
  • Eukaryotic Initiation Factors / genetics*
  • Evolution, Molecular
  • Fungal Proteins / genetics
  • Phylogeny
  • Protein Structure, Tertiary / genetics
  • RNA Helicases / genetics*
  • RNA Helicases / physiology*
  • RNA, Messenger / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Schizosaccharomyces pombe Proteins*
  • Yeasts / enzymology*
  • Yeasts / genetics


  • Cell Cycle Proteins
  • Eukaryotic Initiation Factors
  • Fungal Proteins
  • RNA, Messenger
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Eukaryotic Initiation Factor-4A
  • sum3 protein, S pombe
  • DED1 protein, S cerevisiae
  • DEAD-box RNA Helicases
  • RNA Helicases