A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

Ann Karen C Brassinga; Margot F Hiltz; Gary R Sisson; Michael G Morash; Nathan Hill; Elizabeth Garduno; Paul H Edelstein; Rafael A Garduno; Paul S Hoffman

doi:10.1128/JB.185.15.4630-4637.2003

A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila

J Bacteriol. 2003 Aug;185(15):4630-7. doi: 10.1128/JB.185.15.4630-4637.2003.

Authors

Ann Karen C Brassinga¹, Margot F Hiltz, Gary R Sisson, Michael G Morash, Nathan Hill, Elizabeth Garduno, Paul H Edelstein, Rafael A Garduno, Paul S Hoffman

Affiliation

¹ Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.

Abstract

Nucleotide sequence analysis of an approximately 80-kb genomic region revealed an approximately 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this approximately 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Bacterial Proteins / chemistry
Bacterial Proteins / genetics*
Chromosomes, Bacterial / genetics*
Cluster Analysis
Humans
Legionella pneumophila / genetics*
Legionella pneumophila / pathogenicity*
Molecular Sequence Data
Multigene Family
Virulence

Substances

Bacterial Proteins