Therapeutic potential of the plasma proteome

Curr Opin Mol Ther. 2003 Jun;5(3):250-7.


Plasma contains numerous and diverse proteins with existing and potential therapeutic value. Plasma has been used clinically as both a source of purified derivatives for treating diseases such as hemophilia, and as a diagnostic medium. Recent research directed towards mining plasma's true potential takes advantage of state-of-the-art proteomic analytical methods to develop multi-protein, disease-specific biomarker panels to improve the reliability and specificity of diagnostics. Recombinant production and chromatographic purification methods are increasing the yield and safety of traditional plasma derivatives. Emerging cell-based technologies are being applied to discover novel protein activities and identify epitope-specific antibodies that may have clinical promise.

Publication types

  • Review

MeSH terms

  • Antibodies / therapeutic use
  • Biomarkers / blood
  • Blood Proteins / metabolism*
  • Blood Proteins / therapeutic use*
  • Humans
  • Molecular Diagnostic Techniques*
  • Proteome*


  • Antibodies
  • Biomarkers
  • Blood Proteins
  • Proteome