Biological Role of p300 in Cardiac Myocytes

Mol Cell Biochem. 2003 Jun;248(1-2):115-9. doi: 10.1023/a:1024132217870.

Abstract

A cellular target of adenovirus E1A oncoprotein, p300 is a transcriptional coactivator required for the maintenance of differentiated phenotypes in cardiac myocytes. The full transcriptional activities of hypertrophy-responsive transcription factors such as GATA-4 and MEF2 require interaction with p300. A p300 protein also possesses intrinsic histone acetyl transferase activity, which promotes a transcriptionally active chromatin configuration. Here, we review the biological functions of p300 in cardiac myocytes. Although p300 is biologically active in many cell types, this protein appears to play a crucial role in the differentiation, growth and apoptosis of cardiac myocytes. Understanding precise mechanisms of its biological functions will shed light on molecular pathways for heart failure.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Differentiation
  • Cell Division
  • Fibroblasts / metabolism
  • Humans
  • Models, Biological
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / metabolism*
  • Nuclear Proteins / physiology*
  • Phenotype
  • Protein Binding
  • Trans-Activators / physiology*
  • Transcription, Genetic

Substances

  • Nuclear Proteins
  • Trans-Activators