Effects of pentoxifylline on alcohol-induced gastric injury and acid secretion in rats

Dig Dis Sci. 2003 Jul;48(7):1392-6. doi: 10.1023/a:1024290615796.


We aimed to evaluate the protective effects of pentoxifylline on alcohol-induced gastric injury, its relation with nitric oxide and prostaglandin synthesis, as well as gastric acidity in rats. Acute gastric mucosal injury was induced by intragastric infusion of 2 ml 98% alcohol. Pentoxifylline was given at 100 mg/kg intraperitoneally. Indomethacin and N(G)-nitro-L arginine were used to inhibit prostaglandin and nitric oxide synthesis, respectively. Macroscopic and microscopic gastric injuries were evaluated. Gastric pH, tissue malondialdehyde levels, oxidized and reduced glutathion (GSSG/GSH) levels, and effects of pentoxifylline on gastric acid output were measured. Pentoxifylline pretreatment significantly reduced macroscopic and microscopic gastric injury. Malondialdehyde level was lower in pentoxifylline treated rats (351.1 +/- 94.1 nmol/g vs 624.3 +/- 234.2 nmol/g). Pentoxifylline has a protective role on alcohol-induced gastric mucosal injury in rats. This effect is not related to synthesis of prostaglandins and changes in gastric acidity but does seem to be related to nitric oxide-mediated pathways. In contrast, pentoxifylline increases gastric acid output significantly.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Animals
  • Ethanol
  • Gastric Acid / metabolism
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Male
  • Nitric Oxide / metabolism
  • Pentoxifylline / pharmacology*
  • Protective Agents / pharmacology*
  • Rats
  • Stomach Diseases / chemically induced
  • Stomach Diseases / metabolism*
  • Stomach Diseases / prevention & control*


  • Protective Agents
  • Nitric Oxide
  • Ethanol
  • Pentoxifylline