Choleretic actions of insulin-like growth factor-I, prednisolone, and ursodeoxycholic acid in rats

Dig Dis Sci. 2003 Jul;48(7):1398-405. doi: 10.1023/a:1024140116705.


A recent study by our group demonstrated that a 1-week infusion of insulin-like growth factor-I increases bile flow volume and bile acid secretion in rats, suggesting it is important in in vivo choleresis. In the present study, the effect in rats of a single administration of insulin-like growth factor-I on bile flow volume was investigated and compared with the choleretic drugs prednisolone and ursodeoxycholic acid. A significant and long-lasting increase in bile flow volume was observed in rats treated with insulin-like growth factor-I or prednisolone. Ursodeoxycholic acid significantly, but transiently increased. Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume. Overall, this study demonstrated that the stimulatory effect of insulin-like growth factor-I on bile flow volume is almost equally potent to that of prednisolone and ursodeoxycholic acid, indicating the possible therapeutic potential of insulin-like growth factor-I in cholestatic liver diseases.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Animals
  • Bile / drug effects*
  • Bile / physiology
  • Cholagogues and Choleretics / pharmacology*
  • Digestive System Physiological Phenomena / drug effects*
  • Insulin-Like Growth Factor I / pharmacology*
  • Male
  • Prednisolone / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Ursodeoxycholic Acid / pharmacology*


  • Cholagogues and Choleretics
  • Insulin-Like Growth Factor I
  • Ursodeoxycholic Acid
  • Prednisolone