Cytochrome C is a hydrogen peroxide scavenger in mitochondria

Protein Pept Lett. 2003 Jun;10(3):247-53. doi: 10.2174/0929866033479013.

Abstract

The ability of succinate cytochrome c reductase (SCR) reduced cytochrome c to scavenge H(2)O(2) was investigated. H(2)O(2), whether added or produced by SCR, was efficiently removed when cytochrome c was reduced by SCR. On the other hand, ferrocytochrome c underwent re-oxidization when H(2)O(2) was added. Thus, these results indicate that cytochrome c reduced by succinate cytochrome c reductase has the ability to regulate H(2)O(max) in mitochondria.

MeSH terms

  • Animals
  • Cytochrome c Group / metabolism*
  • Electron Spin Resonance Spectroscopy
  • Electron Transport
  • Free Radical Scavengers / metabolism*
  • Hydrogen Peroxide / metabolism*
  • Hydroxyl Radical / metabolism*
  • Mitochondria, Heart / enzymology*
  • Oxidation-Reduction
  • Succinate Cytochrome c Oxidoreductase / metabolism*
  • Swine

Substances

  • Cytochrome c Group
  • Free Radical Scavengers
  • Hydroxyl Radical
  • Hydrogen Peroxide
  • Succinate Cytochrome c Oxidoreductase