Inhibitors of sialyltransferases: potential roles in tumor growth and metastasis

Mini Rev Med Chem. 2003 Sep;3(6):501-17. doi: 10.2174/1389557033487881.


For over thirty years it has been evident that there is altered glycosyltransferase activity in neoplastic tissue when compared to healthy tissue. It has also long been speculated that disruption of the neoplastic expression of sialic acid on cellular glycoconjugates, is a valid target in anti-metastatic therapeutic development. Over the years attempts have been made to synthesize inhibitors of sialyltransferases in a effort to assist in the validation or dissolution of these enzymes as potential therapeutic targets.

Publication types

  • Review

MeSH terms

  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Molecular Structure
  • Neoplasm Metastasis / prevention & control
  • Neoplasms / drug therapy
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Sialic Acids / metabolism
  • Sialyltransferases / antagonists & inhibitors*
  • Sialyltransferases / metabolism
  • Structure-Activity Relationship


  • Enzyme Inhibitors
  • Sialic Acids
  • Sialyltransferases