Fibrinogen gamma chain functions

J Thromb Haemost. 2003 Feb;1(2):231-8. doi: 10.1046/j.1538-7836.2003.00063.x.

Abstract

This review covers the functional features of the fibrinogen gamma chains including their participation in fibrin polymerization and cross-linking, their role in the initiation of fibrinolysis, their binding and regulation of factor XIII activity, their interactions with platelets and other cells, and their role in mediating thrombin binding to fibrin, a thrombin inhibitory function termed 'antithrombin I'.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Binding Sites
  • Blood Platelets / physiology
  • Cross-Linking Reagents
  • Fibrin / chemistry
  • Fibrin / physiology
  • Fibrinogen / chemistry
  • Fibrinogen / physiology*
  • Fibrinolysis
  • Humans
  • Integrins / physiology
  • Peptide Fragments / chemistry
  • Peptide Fragments / physiology*
  • Plasminogen / physiology
  • Tissue Plasminogen Activator / physiology

Substances

  • Cross-Linking Reagents
  • Integrins
  • Peptide Fragments
  • Fibrin
  • Fibrinogen
  • Plasminogen
  • Tissue Plasminogen Activator