[Effect of fuzheng yiliu granule on nuclear transcriptional factor-kappa B and cell cycle in patients with breast carcinoma]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Jun;23(6):421-2.
[Article in Chinese]


Objective: To explore the effect and clinical significance of Fuzheng Yiliu Granule (FYG) on nuclear transcriptional factor-kappa B (NF-kappa B) and cell cycle in breast tumor.

Methods: Fifty-five patients of breast carcinoma were randomly divided into the treated group and the control group, both were treated with conventional chemotherapy, but to the treated group, FYG was given additionally by oral taking. Operation was performed one month later to take out the tumor tissue for detecting NF-kappa B expression and ration of cells in different phases of cell cycle.

Results: Compared with the control group, NF-kappa B expression was significantly increased in the treated group, accompanied with increased G0/1 phase cell proportion and decreased S phase cell proportion as well as significantly reduced cell proliferation index (all P < 0.01).

Conclusion: FYG could enhance the expression of NF-kappa B in breast tumor tissue, raise the proportion of G0/1 phase cells, decrease proportion S phase cells and reduce the cell proliferation index, showing an active action on the patients prognosis.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / drug therapy*
  • Carcinoma, Ductal, Breast / metabolism
  • Carcinoma, Ductal, Breast / pathology
  • Cell Cycle / drug effects
  • Cell Division / drug effects
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Middle Aged
  • NF-kappa B / biosynthesis*
  • NF-kappa B / genetics
  • Phytotherapy*


  • Drugs, Chinese Herbal
  • NF-kappa B