Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields

Mech Ageing Dev. 2003 Jul;124(7):847-50. doi: 10.1016/s0047-6374(03)00125-8.

Abstract

Several studies indicating a decline of DNA repair efficiency with age raise the question, if senescence per se leads to a higher susceptibility to DNA damage upon environmental exposures. Cultured fibroblasts of six healthy donors of different age exposed to intermittent ELF-EMF (50 Hz sinus, 1 mT) for 1-24 h exhibited different basal DNA strand break levels correlating with age. The cells revealed a maximum response at 15-19 h of exposure. This response was clearly more pronounced in cells from older donors, which could point to an age-related decrease of DNA repair efficiency of ELF-EMF induced DNA strand breaks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Cells, Cultured
  • Child
  • DNA Damage / physiology*
  • DNA Repair / physiology
  • Electromagnetic Fields / adverse effects*
  • Female
  • Fibroblasts / physiology*
  • Fibroblasts / radiation effects
  • Humans
  • Male
  • Middle Aged