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. 2003 Jul 16;42(2):246-52.
doi: 10.1016/s0735-1097(03)00575-8.

Vitamin C and Risk of Coronary Heart Disease in Women

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Vitamin C and Risk of Coronary Heart Disease in Women

Stavroula K Osganian et al. J Am Coll Cardiol. .
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Abstract

Objectives: Our objective was to prospectively examine the relation between vitamin C intake and risk of coronary heart disease (CHD) in women.

Background: Results from prospective investigations of the relation between vitamin C intake and risk of CHD have been inconsistent. The lack of clear evidence for a protective association despite a plausible mechanism indicates the need to evaluate further the association between vitamin C intake and risk of CHD.

Methods: In 1980, 85,118 female nurses completed a detailed semiquantitative food-frequency questionnaire that assessed their consumption of vitamin C and other nutrients. Nurses were followed up for 16 years for the development of incident CHD (nonfatal myocardial infarction and fatal CHD).

Results: During 16 years of follow-up (1,240,566 person-years), we identified 1,356 incident cases of CHD. After adjustment for age, smoking, and a variety of other coronary risk factors, we observed a modest significant inverse association between total intake of vitamin C and risk of CHD (relative risk [RR] = 0.73; 95% confidence interval [CI] 0.57 to 0.94). Among women who did not use vitamin C supplements or multivitamins, the association between intake of vitamin C from diet alone and incidence of CHD was weak and not significant (RR = 0.86; 95% CI 0.59 to 1.26). In multivariate models adjusting for age, smoking, and a variety of other coronary risk factors, vitamin C supplement use was associated with a significantly lower risk of CHD (RR = 0.72; 95% CI 0.61 to 0.86).

Conclusions: Users of vitamin C supplements appear to be at lower risk for CHD.

Comment in

  • To C or not to C, that is the question!
    Frei B. Frei B. J Am Coll Cardiol. 2003 Jul 16;42(2):253-5. doi: 10.1016/s0735-1097(03)00574-6. J Am Coll Cardiol. 2003. PMID: 12875760 Review. No abstract available.

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