Coping and the ineffectiveness of coping influence the outcome of in vitro fertilization through stress responses

Psychoneuroendocrinology. 1992 Nov;17(6):655-65. doi: 10.1016/0306-4530(92)90024-2.


The effect of a coping-ineffectiveness of coping construct and of psychoendocrine stress responses upon the outcome of in vitro fertilization treatment was investigated in 40 women. Women with a high Zung depression score, high active coping, high avoidance, and a high expression of emotion have lower pregnancy rates. The mechanisms for this personality effect are not clear, although the desensitization-stimulation process (FSH, E2 concentrations) seems to be involved. The psychoendocrinological responses to the stress of oocyte retrieval and embryo transfer are important: Women with high anticipatory state anxiety levels and high anticipatory cortisol concentrations have lower pregnancy rates. The influence of prolactin stress concentrations is unclear: Women with high prolactin concentrations seem to have more oocytes but lower fertilization rates.

MeSH terms

  • Adaptation, Psychological / physiology*
  • Adult
  • Anxiety / blood
  • Anxiety / psychology
  • Arousal / physiology*
  • Depression / blood
  • Depression / psychology
  • Embryo Transfer / psychology
  • Female
  • Fertilization in Vitro*
  • Follicle Stimulating Hormone / blood
  • Humans
  • Hydrocortisone / blood
  • Luteinizing Hormone / blood
  • Pregnancy / physiology*
  • Prolactin / blood


  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Hydrocortisone