Methylated DNA as a possible screening marker for neoplastic disease in several body fluids

Expert Rev Mol Diagn. 2003 Jul;3(4):443-58. doi: 10.1586/14737159.3.4.443.

Abstract

Early detection appears to be one of the most important approaches to reducing mortality caused by neoplasia. Changes in DNA methylation have been recognized as one of the most common molecular alterations in human tumors. Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Body Fluids / chemistry*
  • DNA Methylation*
  • DNA, Neoplasm / analysis*
  • Female
  • Humans
  • Mass Screening*
  • Molecular Diagnostic Techniques
  • Neoplasms / diagnosis*
  • Neoplasms / genetics

Substances

  • Biomarkers, Tumor
  • DNA, Neoplasm