Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye

Brain Res Mol Brain Res. 2003 Jul 23;115(2):196-201. doi: 10.1016/s0169-328x(03)00173-6.

Abstract

Here we clone the Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / embryology
  • Brain / metabolism*
  • Bromodeoxyuridine / pharmacokinetics
  • Cloning, Molecular
  • Cyclin D1 / genetics
  • Cyclin D1 / metabolism
  • Embryo, Nonmammalian
  • Eye / embryology
  • Eye / metabolism*
  • Gene Expression Regulation, Developmental*
  • Genetic Markers
  • In Situ Hybridization
  • Larva / genetics
  • Larva / metabolism
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • RNA, Messenger / biosynthesis
  • Radiation-Sensitizing Agents / pharmacokinetics
  • Receptor, Notch1
  • Receptor, Serotonin, 5-HT2A
  • Receptor, Serotonin, 5-HT2B
  • Receptors, Cell Surface*
  • Receptors, Serotonin / genetics
  • Receptors, Serotonin / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Transcription Factors*
  • Xenopus / genetics
  • Xenopus Proteins / metabolism

Substances

  • Genetic Markers
  • Membrane Proteins
  • RNA, Messenger
  • Radiation-Sensitizing Agents
  • Receptor, Notch1
  • Receptor, Serotonin, 5-HT2A
  • Receptor, Serotonin, 5-HT2B
  • Receptors, Cell Surface
  • Receptors, Serotonin
  • Transcription Factors
  • Xenopus Proteins
  • Cyclin D1
  • Bromodeoxyuridine