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, 23 (5), 211-5

Mycoplasma Blood Infection in Chronic Fatigue and Fibromyalgia Syndromes


Mycoplasma Blood Infection in Chronic Fatigue and Fibromyalgia Syndromes

Gerhard K M Endresen. Rheumatol Int.


Chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) are characterised by a lack of consistent laboratory and clinical abnormalities. Although they are distinguishable as separate syndromes based on established criteria, a great number of patients are diagnosed with both. In studies using polymerase chain reaction methods, mycoplasma blood infection has been detected in about 50% of patients with CFS and/or FMS, including patients with Gulf War illnesses and symptoms that overlap with one or both syndromes. Such infection is detected in only about 10% of healthy individuals, significantly less than in patients. Most patients with CFS/FMS who have mycoplasma infection appear to recover and reach their pre-illness state after long-term antibiotic therapy with doxycycline, and the infection can not be detected after recovery. By means of causation and therapy, mycoplasma blood infection may permit a further subclassification of CFS and FMS. It is not clear whether mycoplasmas are associated with CFS/FMS as causal agents, cofactors, or opportunistic infections in patients with immune disturbances. Whether mycoplasma infection can be detected in about 50% of all patient populations with CFS and/or FMS is yet to be determined.

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    1. Clin Diagn Lab Immunol. 2002 Jul;9(4):747-52 - PubMed
    1. Annu Rev Microbiol. 1994;48:687-712 - PubMed
    1. J Clin Microbiol. 1989 Nov;27(11):2492-6 - PubMed
    1. Ann Intern Med. 2001 May 1;134(9 Pt 2):868-81 - PubMed
    1. Arch Intern Med. 1998 Feb 23;158(4):367-71 - PubMed

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