Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease

Bioessays. 2003 Aug;25(8):767-80. doi: 10.1002/bies.10306.


c-Rel is a proto-oncogene first identified as the cellular counterpart of the v-Rel oncogene derived from the avian reticuloendotheliosis retrovirus (REV-T). It was subsequently discovered that c-Rel belongs to the NF-kappaB/Rel transcription factor family whose members share a common DNA recognition motif and similar signaling pathways. Despite the similarities, however, each NF-kappaB/Rel member possesses unique properties with regard to tissue expression pattern, response to receptor signals and target gene specificity. These differences are fairly evident from the non-redundant phenotypes exhibited by individual NF-kappaB/Rel knockout mice. Hence the work described in this review will compare and contrast the various physiological functions of c-Rel to those of other NF-kappaB members, particularly with respect to the regulation of proliferation, survival and effector functions in multiple hematopoietic and immunological cell types. The study of c-Rel knockout mice in several disease models will also be discussed as they reveal an important role for c-Rel in response to allergens, auto-antigens, allo-antigens and pathogenic infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Genes, rel
  • Hematopoiesis
  • Hypersensitivity / immunology
  • Infections / immunology
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • NF-kappa B / immunology*
  • Proto-Oncogene Proteins c-rel / immunology*
  • Signal Transduction


  • NF-kappa B
  • Proto-Oncogene Proteins c-rel