Within-subject variability of BOLD response dynamics

Neuroimage. 2003 Jul;19(3):784-96. doi: 10.1016/s1053-8119(03)00177-0.


In this paper we investigate the within-subject variability of dynamical aspects of the BOLD response obtained in a series of fMRI sessions several days apart. Five different parameters describing the temporal behavior of trial-averaged time courses, such as time-to-peak and time-to-onset, were estimated and analyzed with respect to their variability across nine sessions. Results show that small variances of the estimated parameters can be found, provided that the analysis is restricted to voxels activated in all individual sessions. Among the investigated parameters, time-to-peak shows the most stable behavior. These results were obtained using two different analysis methods, the estimation of the parameters directly from trial-averaged time courses and fitting trial-averaged time courses to an assumed hemodynamic response function. Both methods yield comparable results.

MeSH terms

  • Adult
  • Algorithms
  • Brain Chemistry / physiology*
  • Brain Mapping
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / physiology
  • Cerebrovascular Circulation / physiology
  • Female
  • Frontal Lobe / blood supply
  • Frontal Lobe / metabolism
  • Frontal Lobe / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Oxygen / blood*
  • Parietal Lobe / blood supply
  • Parietal Lobe / metabolism
  • Parietal Lobe / physiology
  • Psychomotor Performance / physiology
  • Reproducibility of Results
  • Visual Cortex / blood supply
  • Visual Cortex / metabolism
  • Visual Cortex / physiology


  • Oxygen