Treating coagulopathy in trauma patients

Transfus Med Rev. 2003 Jul;17(3):223-31. doi: 10.1016/s0887-7963(03)00022-1.


Coagulopathy in patients with severe trauma is related to platelet and coagulation factor loss, consumption, and dysfunction. It is exacerbated by dilution, acidosis, and hypothermia. Hemorrhage control, warming, and appropriate blood product support are lifesaving. Further improvements in hemorrhage control will save additional lives and resources.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acidosis
  • Blood Coagulation Factors / therapeutic use
  • Blood Transfusion
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / etiology
  • Disseminated Intravascular Coagulation / therapy*
  • Hemodilution
  • Hemorrhage / etiology
  • Humans
  • Hypothermia
  • Kidney / injuries
  • Liver / injuries
  • Wounds and Injuries / complications*


  • Blood Coagulation Factors