[Familial susceptibility to aminoglycoside ototoxicity due to the A1555G mutation in the mitochondrial DNA]

Med Clin (Barc). 2003 Jul 12;121(6):216-8. doi: 10.1016/s0025-7753(03)73909-8.
[Article in Spanish]


Background and objective: The A1555G mutation in the mitochondrial genome causes sensorineural hearing loss and familial aminoglycoside ototoxicity.

Patients and method: Screening for the A1555G mutation was performed on 72 patients with nonsyndromic sensorineural hearing loss.

Results: The A1555G mutation was identified in 15 patients (20.8%). All of them presented maternal relatives with deafness. Individuals with the A1555G mutation that had been treated with aminoglycosides developed more severe hearing loss.

Conclusions: The A1555G mutation should be screened in individuals with maternal relatives with hearing loss before administering aminoglycosides.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aminoglycosides
  • Anti-Bacterial Agents / adverse effects*
  • Child
  • Child, Preschool
  • DNA, Mitochondrial / genetics*
  • Female
  • Hearing Loss / chemically induced*
  • Hearing Loss / genetics*
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Pedigree


  • Aminoglycosides
  • Anti-Bacterial Agents
  • DNA, Mitochondrial