Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis

Clin Infect Dis. 2003 Aug 1;37(3):319-25. doi: 10.1086/375819. Epub 2003 Jul 15.


A longitudinal cohort study of sexually active women 18-30 years of age was conducted to identify variables associated with the acquisition of herpes simplex virus type 2 (HSV-2) infections. Six hundred seventy HSV-2-seronegative women were followed up at 4-month intervals for 1 year; acquisition of HSV-2 antibodies was detected in 32 of these women. Black race, < or =12 years of education, having a new sex partner, and bacterial vaginosis (BV) were associated with HSV-2 seroconversion on univariate analysis. Antecedent HSV-1 infection was not protective against HSV-2 acquisition. After controlling for other identified risk factors in multivariable models, the diagnosis of BV remained associated with an increased risk of acquiring HSV-2 infection (hazard ratio, 2.1; 95% confidence interval, 1.0-4.5; P=.05). In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Cohort Studies
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Herpes Simplex / complications*
  • Herpes Simplex / epidemiology
  • Herpes Simplex / ethnology
  • Herpesvirus 2, Human*
  • Humans
  • Longitudinal Studies
  • Polymerase Chain Reaction
  • Pregnancy
  • Risk Factors
  • Vaginosis, Bacterial / complications*
  • Vaginosis, Bacterial / epidemiology
  • Vaginosis, Bacterial / ethnology