Role of MAP kinase in tumor progression and invasion

Cancer Metastasis Rev. 2003 Dec;22(4):395-403. doi: 10.1023/a:1023781114568.


Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis
  • Cell Movement
  • Disease Progression
  • Humans
  • MAP Kinase Signaling System*
  • Models, Biological
  • Neoplasm Invasiveness
  • Neoplasms / enzymology
  • Neoplasms / pathology*
  • Neovascularization, Pathologic
  • Signal Transduction