To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures included weight, VO2max, blood pressure (BP), and serum concentrations of vitamin E and lipid hydroperoxide (LOOH). At the end of the 16-week trial, the EGP and EGE had significant increases in VO2max and significant decreases in resting BP, weight, and LOOH concentrations (P < 0.05). The SGE had significant decreases in LOOH and BP (P < 0.05). There were no significant changes in the SGP (P > 0.05). The results suggest that endurance exercise in combination with vitamin E reduces oxidative stress, improves aerobic fitness, and reduces BP and weight in older adults. Even sedentary participants who take vitamin E may reduce oxidative stress and lower BP.