Alzheimer's disease as a disconnection syndrome?

Neuropsychol Rev. 2003 Jun;13(2):79-92. doi: 10.1023/a:1023832305702.


This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / pathology*
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / psychology
  • Brain Mapping
  • Cerebral Cortex / pathology*
  • Cerebral Cortex / physiopathology
  • Diagnostic Imaging
  • Dominance, Cerebral / physiology*
  • Humans
  • Neural Pathways / pathology*
  • Neural Pathways / physiopathology
  • Neurofibrillary Tangles / pathology
  • Neuropsychological Tests
  • Plaque, Amyloid / pathology