Abstract
The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.
MeSH terms
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Catalytic Domain / genetics
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Chromosomes / genetics*
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Dosage Compensation, Genetic*
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Eukaryotic Cells / metabolism*
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Gene Expression Regulation, Enzymologic / genetics
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Histones / genetics*
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Humans
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Silencer Elements, Transcriptional / genetics*
Substances
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Histones
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macroH2A histone
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Adenosine Diphosphate Ribose