Inactivating chromosomes: a macro domain that minimizes transcription

Mol Cell. 2003 Jul;12(1):1-3. doi: 10.1016/s1097-2765(03)00284-3.

Abstract

The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.

Publication types

  • Review

MeSH terms

  • Adenosine Diphosphate Ribose / metabolism
  • Animals
  • Catalytic Domain / genetics
  • Chromosomes / genetics*
  • Dosage Compensation, Genetic*
  • Eukaryotic Cells / metabolism*
  • Gene Expression Regulation, Enzymologic / genetics
  • Histones / genetics*
  • Humans
  • Silencer Elements, Transcriptional / genetics*

Substances

  • Histones
  • macroH2A histone
  • Adenosine Diphosphate Ribose