Alterations in retinal nerve fiber layer thickness following indirect traumatic optic neuropathy detected by nerve fiber analyzer, GDx-N

Am J Ophthalmol. 2003 Aug;136(2):361-4. doi: 10.1016/s0002-9394(03)00199-5.


Purpose: To evaluate changes in the retinal nerve fiber layer following traumatic optic neuropathy.

Design: Observational case report.

Methods: A patient presented with visual loss after an accident. Scanning laser polarimetry was performed.

Results: Thickness of the retinal nerve fiber layer increased immediately after the trauma but then progressively decreased. Severe loss was observed at day 90 and then ceased. Enlargement of the optic disk cup was also observed.

Conclusions: This is the first report documenting early transient increase followed by progressive loss of the retinal nerve fiber layer in traumatic optic neuropathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bicycling / injuries
  • Diagnostic Techniques, Ophthalmological*
  • Glucocorticoids / therapeutic use
  • Humans
  • Lasers
  • Male
  • Methylprednisolone / therapeutic use
  • Nerve Fibers / drug effects
  • Nerve Fibers / pathology*
  • Optic Nerve / drug effects
  • Optic Nerve / pathology*
  • Optic Nerve Injuries / diagnosis*
  • Optic Nerve Injuries / drug therapy
  • Optic Nerve Injuries / physiopathology
  • Retinal Ganglion Cells / drug effects
  • Retinal Ganglion Cells / pathology*
  • Vision Disorders / diagnosis
  • Vision Disorders / drug therapy
  • Vision Disorders / physiopathology
  • Visual Fields


  • Glucocorticoids
  • Methylprednisolone