[Detection of carriers of hemophilia B]

Cas Lek Cesk. 1992 Dec 4;131(24-25):761-3.
[Article in Czech]


Thirty-two families with haemophilia B were divided into sub-groups based on assessment of fIX:Ag, fIX:C and the thromboplastin time with bovine thromboplastin. In confirmed carriers from these families after assessment of fIX:Ag and, fIX:C the normal range of individual sub-groups of confirmed carriers was assessed and compared with values of fiX:Ag and fiX:C of the control group. It will be possible to use these groups after their extension to assess probable carriers in sub-groups CRM+ and CRM-. In the sub-group CRMR the only criterium of transmission is a reduced fIX:C level. A prolonged TP with bovine thromboplastin in families with BM haemophilia cannot be used to assess carriers.

MeSH terms

  • Adult
  • Female
  • Genetic Carrier Screening* / methods
  • Hemophilia B / diagnosis*
  • Humans
  • Middle Aged