Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET

J Neuroimaging. 2003 Jul;13(3):269-71.


The effect of chemotherapy with procarbazine, CCNU, and vincristine in an anaplastic oligoastrocytoma was monitored by repeated positron emission tomography (PET) with C-11-methionine (C-11-MET). Chemotherapy caused a continuous decline of active tumor volume at a rate of approximately 2.4% per day, resulting in complete remission that persisted until the end of follow-up at 3 years. Thus, the authors conclude that C-11-MET PET may be useful for monitoring chemotherapy in gliomas and deserves further study.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Astrocytoma / diagnostic imaging*
  • Astrocytoma / drug therapy
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / drug therapy
  • Cerebral Cortex / diagnostic imaging*
  • Cerebral Cortex / drug effects
  • Chemotherapy, Adjuvant
  • Drug Monitoring / methods*
  • Female
  • Humans
  • Methionine
  • Radiopharmaceuticals
  • Tomography, Emission-Computed / methods*
  • Treatment Outcome


  • Radiopharmaceuticals
  • carbon-11 methionine
  • Methionine