[A comparative study of EGFR and FGFR-2 expression in fetal and adult skin]

Zhonghua Zheng Xing Wai Ke Za Zhi. 2003 Mar;19(2):91-4.
[Article in Chinese]


Objective: To observe the expression characteristics of EGFR and FGFR-2 in normal skin from fetal and adult, and attempted to probe the molecule mechanism of fetal scarless healing.

Methods: The skin samples of fetal and adult were taken from abortive fetus of obstetrics unit and donor site of plastic operation patients in our burn unit, respectively. EGFR and FGFR-2 were used as the biochemical markers for reparative cells. Immunohistochemistry staining technique was employed to determine the expressive levels of different epithelial cells markers.

Results: There were EGFR and FGFR-2 antibody positive cells in normal skin from fetal and adult, but the expressive levels of EGFR and FGFR-2 protein had apparent difference, with the time of fetation increasing, the EGFR and FGFR-2 positive expression rate became stronger gradually. The number of FGFR-2 antibody positive cells found in adult skin was much more than that in fetal skin.

Conclusion: There were the inherent differences of EGFR and FGFR-2 antibody immunohistochemistry staining in cells of adult and fetal skin. which may be an essential facet of fetal scarless healing.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Epithelial Cells / metabolism
  • ErbB Receptors / metabolism*
  • Female
  • Fetus / metabolism*
  • Humans
  • Immunohistochemistry
  • Receptor, ErbB-2 / metabolism*
  • Skin / metabolism*
  • Wound Healing*


  • ErbB Receptors
  • Receptor, ErbB-2