[Withdrawal symptoms in a neonate following exposure to venlafaxine during pregnancy]

Ned Tijdschr Geneeskd. 2003 Jul 12;147(28):1370-2.
[Article in Dutch]


Withdrawal symptoms occurred in a male neonate after maternal use of venlafaxine for depression during pregnancy. The symptoms were restlessness, hypertonia, jitteriness, irritability and poor feeding. The diagnosis was confirmed by a temporary improvement after administration of a low dose (1 mg) of venlafaxine to the boy. Eventually the symptoms began to decline spontaneously, and ceased after 8 days. Exposure to venlafaxine and other antidepressants which inhibit serotonin reuptake during the third trimester of pregnancy carries the risk of a neonatal withdrawal syndrome.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antidepressive Agents, Second-Generation / adverse effects*
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Cyclohexanols / adverse effects*
  • Cyclohexanols / therapeutic use
  • Depression / drug therapy
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Neonatal Abstinence Syndrome*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Serotonin Uptake Inhibitors / adverse effects*
  • Serotonin Uptake Inhibitors / therapeutic use
  • Venlafaxine Hydrochloride


  • Antidepressive Agents, Second-Generation
  • Cyclohexanols
  • Serotonin Uptake Inhibitors
  • Venlafaxine Hydrochloride