Depression, mortality, and medical morbidity in patients with coronary heart disease

Biol Psychiatry. 2003 Aug 1;54(3):241-7. doi: 10.1016/s0006-3223(03)00111-2.


There is substantial evidence that depression is a risk factor for cardiac morbidity and mortality, both for patients without clinical evidence of coronary heart disease at index examination and for patients with established coronary disease. The relationship is most apparent for patients with a recent acute myocardial infarction. Many questions about the impact of depression on heart disease remain unresolved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Comorbidity
  • Coronary Disease / mortality*
  • Depression / mortality
  • Depressive Disorder / mortality*
  • Depressive Disorder / physiopathology
  • Humans
  • Myocardial Infarction / mortality
  • United States / epidemiology