Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori

Cancer Lett. 2003 Jul 30;198(1):37-42. doi: 10.1016/s0304-3835(03)00285-4.


To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Cells, Cultured
  • Cocarcinogenesis
  • Female
  • Lymphocytes
  • Mice
  • Mice, Inbred ICR
  • Momordica / chemistry*
  • Peroxynitrous Acid / pharmacology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control
  • Sweetening Agents / pharmacology*
  • Tetradecanoylphorbol Acetate
  • Triterpenes / pharmacology*


  • 11-oxo-mogroside V
  • Anticarcinogenic Agents
  • Sweetening Agents
  • Triterpenes
  • Peroxynitrous Acid
  • 9,10-Dimethyl-1,2-benzanthracene
  • mogroside V
  • Tetradecanoylphorbol Acetate