Necrolytic migratory erythema as the only presenting sign of a glucagonoma

J Am Acad Dermatol. 2003 Aug;49(2):325-8. doi: 10.1067/s0190-9622(02)61774-8.


We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being 130 pg/mL. Computed tomographic scan of the abdomen revealed a 5-cm mass in the tail of the pancreas. The tumor was removed and found to be a glucagonoma (pancreatic islet tumor). The clinical eruption resolved promptly with surgical excision. Neither the clinical eruption nor the tumor has recurred for 6 months. The course of disease confirms the diagnosis of necrolytic migratory erythema associated with a glucagonoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Erythema / etiology*
  • Erythema / pathology
  • Glucagonoma / complications
  • Glucagonoma / diagnosis*
  • Humans
  • Male
  • Necrosis
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / diagnosis*