The emerging role of lysophosphatidic acid in cancer

Nat Rev Cancer. 2003 Aug;3(8):582-91. doi: 10.1038/nrc1143.


The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Heterotrimeric GTP-Binding Proteins / metabolism
  • Humans
  • Lysophospholipids / analysis
  • Lysophospholipids / chemistry
  • Lysophospholipids / physiology*
  • Neoplasms / diagnosis
  • Neoplasms / etiology*
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled*
  • Receptors, Lysophosphatidic Acid
  • Signal Transduction


  • Biomarkers, Tumor
  • Lysophospholipids
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Heterotrimeric GTP-Binding Proteins