Control of gut differentiation and intestinal-type gastric carcinogenesis

Nat Rev Cancer. 2003 Aug;3(8):592-600. doi: 10.1038/nrc1141.


Gastric cancer is one of the world's most common cancers. Its carcinogenic pathway is mainly associated with Helicobacter pylori infection, subsequent inflammation and tissue regeneration. During the regeneration process, cells deviate from the normal pathway of gastric differentiation to an 'intestinal phenotype', which is thought to be precancerous and associated with the intestinal type of gastric cancer. Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma / classification
  • Carcinoma / etiology*
  • Carcinoma / pathology
  • Cell Differentiation
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Helicobacter Infections / complications
  • Helicobacter pylori
  • Humans
  • Metaplasia
  • Models, Biological
  • Stomach / embryology
  • Stomach Neoplasms / classification
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / pathology
  • Transcription Factors / metabolism


  • Transcription Factors