Hematopoietic prostaglandin D synthase

Prostaglandins Leukot Essent Fatty Acids. Aug-Sep 2003;69(2-3):163-7. doi: 10.1016/s0952-3278(03)00077-2.

Abstract

The biological actions of prostaglandin (PG) D(2) include vasodilatation, bronchoconstriction, inhibition of platelet aggregation, and recruitment of inflammatory cells. Characterization of DP receptor null mice in which antigen-induced airway and inflammatory responses are attenuated and identification of CRTH2 as a novel PGD(2) receptor have shed light on the role of PGD(2) in the immune and inflammatory responses. Hematopoietic PGD synthase (H-PGDS) is a cytosolic enzyme that isomerizes PGH(2), a common precursor for all PGs and thromboxanes, to PGD(2) in a glutathione-dependent manner. H-PGDS is expressed in mast cells, antigen-presenting cells, and Th2 cells, and is the only mammalian member of the Sigma class of cytosolic glutathione S-transferases. In this review, we focus on the molecular biology of H-PGDS, the determination of its three-dimensional structure, characterization of the regulation of its gene expression, and information gleaned from transgenic animals.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Cloning, Molecular
  • Gene Expression
  • Glutathione / metabolism
  • Glutathione Transferase / metabolism
  • Hematopoietic System / enzymology
  • Hematopoietic System / metabolism*
  • Humans
  • Intramolecular Oxidoreductases / biosynthesis
  • Intramolecular Oxidoreductases / genetics
  • Intramolecular Oxidoreductases / metabolism*
  • Lipocalins
  • Mast Cells / metabolism
  • Piperidines / chemistry
  • Piperidines / pharmacology
  • Prostaglandin D2 / metabolism
  • Th2 Cells / metabolism
  • Thromboxane A2 / metabolism

Substances

  • 4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine
  • Lipocalins
  • Piperidines
  • Thromboxane A2
  • Glutathione Transferase
  • Intramolecular Oxidoreductases
  • prostaglandin R2 D-isomerase
  • Glutathione
  • Prostaglandin D2