The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.)

Antiviral Res. 2003 Jul;59(2):121-6. doi: 10.1016/s0166-3542(03)00067-6.

Abstract

We report that the anti-retroviral and anti-hepadnavirus molecules, adefovir, tenofovir and 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine (PMEDAP), efficiently eradicate the episomal form of Banana streak virus (BSV) from banana plants. Up to 90% of plants regenerated from BSV-infected highly proliferating meristems were virus free following a 6-month treatment period with 10 microg/ml (a non-phytotoxic concentration) of either compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Adenine / toxicity
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / toxicity
  • Badnavirus / drug effects*
  • Badnavirus / pathogenicity
  • Badnavirus / physiology
  • Musa / drug effects*
  • Musa / virology*
  • Organophosphonates*
  • Organophosphorus Compounds / pharmacology
  • Organophosphorus Compounds / toxicity
  • Plant Diseases / virology*
  • Reverse Transcriptase Inhibitors / pharmacology
  • Reverse Transcriptase Inhibitors / toxicity
  • Tenofovir
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Reverse Transcriptase Inhibitors
  • 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
  • adefovir
  • Tenofovir
  • Adenine