Th1/Th2 balance in preeclampsia

J Reprod Immunol. 2003 Aug;59(2):161-73. doi: 10.1016/s0165-0378(03)00045-7.


The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system allowing the second physiological trophoblastic invasion. In this review, we discuss that Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation.

Publication types

  • Review

MeSH terms

  • Endothelium, Vascular / immunology
  • Female
  • Humans
  • Inflammation
  • Placentation / immunology
  • Placentation / physiology
  • Pre-Eclampsia / etiology
  • Pre-Eclampsia / immunology*
  • Pre-Eclampsia / physiopathology
  • Pregnancy / immunology*
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*