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Review
. 2003 Aug;4(8):626-37.
doi: 10.1038/nrg1125.

The Power of the 3' UTR: Translational Control and Development

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Review

The Power of the 3' UTR: Translational Control and Development

Scott Kuersten et al. Nat Rev Genet. .

Abstract

Many crucial decisions, such as the location and timing of cell division, cell-fate determination, and embryonic axes establishment, are made in the early embryo, a time in development when there is often little or no transcription. For this reason, the control of variation in gene expression in the early embryo often relies on post-transcriptional control of maternal genes. Although the early embryo is rife with translational control, controlling mRNA activity is also important in other developmental processes, such as stem-cell proliferation, sex determination, neurogenesis and erythropoiesis.

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