The many roles of the transcriptional regulator CTCF

Biochem Cell Biol. 2003 Jun;81(3):161-7. doi: 10.1139/o03-052.


The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CCCTC-Binding Factor
  • DNA / genetics
  • DNA / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Genes, myc / genetics
  • Humans
  • Insulator Elements / genetics
  • Models, Biological
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Transcription, Genetic


  • CCCTC-Binding Factor
  • CTCF protein, human
  • DNA-Binding Proteins
  • Repressor Proteins
  • DNA