Expression of caveolin-1 in gastrointestinal and extraintestinal cancers

J Cancer Res Clin Oncol. 2003 Sep;129(9):493-7. doi: 10.1007/s00432-003-0468-0. Epub 2003 Jul 25.

Abstract

Caveolae are uniform vesicular invaginations of the cell membrane. Caveolin-1 is responsible for the formation of caveolae and plays a key role in membrane traffic and signal transduction. The contribution of caveolin-1 to carcinogenesis has been widely investigated; however, the expression pattern of caveolin-1 is controversial both in gastrointestinal and extraintestinal cancers. Most of the results based on cancer cell line experiments suggest that caveolin-1 might act as a tumor-suppressor gene. On the contrary, several studies on the expression of caveolin-1 in tumor tissues indicate a possible tumor-promoting effect of caveolin-1. In this article we summarize the divergent results of caveolin-1 expression in gastrointestinal and extraintestinal cancer regarding possible future therapeutic implications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caveolin 1
  • Caveolins / metabolism*
  • Gastrointestinal Neoplasms / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Genes, Tumor Suppressor
  • Humans
  • Neoplasms / metabolism*

Substances

  • CAV1 protein, human
  • Caveolin 1
  • Caveolins