Serum levels of beta-trace protein and glomerular filtration rate--preliminary results

J Pharm Biomed Anal. 2003 Aug 8;32(4-5):1099-104. doi: 10.1016/s0731-7085(03)00215-2.

Abstract

The aim of this study was to evaluate the relationship between serum levels of beta-trace protein (BTP), a low molecular weight (MW) protein, and glomerular filtration rate (GFR). GFR and serum levels of BTP, and for comparison creatinine (Creat), cystatin C (Cys) and beta 2-microglobulin (beta 2M), were measured in 60 patients, with renal function ranging from normality to advanced renal failure. Serum levels of BTP progressively increased with the reduction of GFR. A good correlation was found between GFR and serum levels of BTP (r=0.918), Creat (r=0.932), Cys (r=0.937), and beta 2M (r=0.924). Furthermore, no statistically significant difference was found between BTP and Creat, Cys, beta 2M, as indicators of a moderate GFR impairment. These preliminary data indicate that BTP might be suitable as an indicator of GFR.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Creatinine / blood
  • Cystatin C
  • Cystatins / blood
  • Female
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Intramolecular Oxidoreductases / blood*
  • Kidney Diseases / blood
  • Lipocalins
  • Male
  • Middle Aged
  • Reference Values
  • beta 2-Microglobulin / blood

Substances

  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Lipocalins
  • beta 2-Microglobulin
  • Creatinine
  • Intramolecular Oxidoreductases
  • prostaglandin R2 D-isomerase