Fibrin glue for the prevention of epithelial ingrowth after laser in situ keratomileusis

J Cataract Refract Surg. 2003 Jul;29(7):1425-9. doi: 10.1016/s0886-3350(02)01989-2.


We present 3 cases of recurrent epithelial ingrowth following laser in situ keratomileusis. All patients consented to flap lifting, epithelial ingrowth removal, and placement of fibrin glue (Tisseel(R) VH, Baxter) at the flap edges. Two of 3 eyes had no evidence of recurrent epithelial ingrowth within a relatively short follow-up. One eye that also had had radial keratotomy had a small nest of stable epithelial cells that had not progressed. Fibrin glue may be a useful adjunct to prevent recurrent epithelial ingrowth. There were no complications associated with its use.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corneal Diseases / etiology*
  • Corneal Diseases / pathology
  • Corneal Diseases / prevention & control*
  • Epithelium, Corneal* / pathology
  • Female
  • Fibrin Tissue Adhesive / therapeutic use*
  • Humans
  • Keratomileusis, Laser In Situ / adverse effects*
  • Male
  • Middle Aged
  • Tissue Adhesives / therapeutic use*


  • Fibrin Tissue Adhesive
  • Tissue Adhesives